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Clinicopathologic features and diagnostic challenges of small cluster pattern appendiceal neuroendocrine tumors.
Gertsen, Benjamin; Arshi, Juwairiya; Li, Rena X; Findeis-Hosey, Jennifer J; Huber, Aaron R; Hao, Yansheng.
Afiliación
  • Gertsen B; The University of Rochester Medical Center, Dept. Pathology & Laboratory Medicine, Rochester, NY, USA. Electronic address: Benjamin_Gertsen@URMC.Rochester.edu.
  • Arshi J; The University of Rochester Medical Center, Dept. Pathology & Laboratory Medicine, Rochester, NY, USA. Electronic address: Juwairiya_Arshi@URMC.Rochester.edu.
  • Li RX; High School Intern, Pittsford Mendon High School, Pittsford, NY, USA.
  • Findeis-Hosey JJ; The University of Rochester Medical Center, Dept. Pathology & Laboratory Medicine, Rochester, NY, USA. Electronic address: Jennifer_Findeis-hosey@URMC.Rochester.edu.
  • Huber AR; The University of Rochester Medical Center, Dept. Pathology & Laboratory Medicine, Rochester, NY, USA. Electronic address: Aaron_Huber@URMC.Rochester.edu.
  • Hao Y; The University of Rochester Medical Center, Dept. Pathology & Laboratory Medicine, Rochester, NY, USA. Electronic address: Yansheng_Hao@URMC.Rochester.edu.
Ann Diagn Pathol ; 69: 152250, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38142627
ABSTRACT
Appendiceal neuroendocrine neoplasms (NENs) can present with various growth patterns including the traditional triad of histologic patterns-insular, trabecular and tubular. A small cluster pattern was also found in this study and the literature on this specific morphology is limited. In this study, we conducted a comprehensive review of appendiceal NENs from our institution over a ten-year period. Clinical and demographic data were obtained from medical records. Immunohistochemical stains were performed with antibodies specific for synaptophysin, chromogranin, INSM1, CD56, serotonin and peptide YY. The small cluster pattern was found in 29.4 % of all cases evaluated. The tumor cells in these cases were predominantly located at the distal tip of the appendix, associated with fibrous obliteration. These tumors were smaller in size and tended towards less advanced tumor stage, with reduced incidence of lymphovascular and/or perineural invasion. Chromogranin expression was identified in 76 % of these cases. There is a heterogeneous hormone profile with 46.7 % serotonin and 33.3 % peptide YY. In conclusion, the small cluster pattern NENs present with unique histological features and hormone expression profile. Among the various neuroendocrine markers, INSM1 showed superior diagnostic performance, with high sensitivity and minimal non-specific staining.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Neoplasias del Apéndice / Neoplasias Gástricas / Tumores Neuroendocrinos / Carcinoma Neuroendocrino / Neoplasias Intestinales Límite: Humans Idioma: En Revista: Ann Diagn Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Neoplasias del Apéndice / Neoplasias Gástricas / Tumores Neuroendocrinos / Carcinoma Neuroendocrino / Neoplasias Intestinales Límite: Humans Idioma: En Revista: Ann Diagn Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article