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Nickel-Catalyzed C(sp3)-Sb Coupling of Chlorostibines with Unactivated Alkyl Chlorides and In Vitro Anticancer Activity of Products.
Le, Liyuan; Yin, Mingming; Zeng, Huifan; Xie, Wuxing; Zhou, Wenjun; Chen, Yi; Xiong, Biquan; Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua.
Afiliación
  • Le L; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
  • Yin M; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
  • Zeng H; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
  • Xie W; Department of Physiology, School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Zhou W; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
  • Chen Y; Department of Physiology, School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Xiong B; Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, 414006, P. R. China.
  • Yin SF; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
  • Kambe N; College of Science, Central South University of Forestry and Technology, Changsha, 410004, P. R. China.
  • Qiu R; Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Org Lett ; 26(1): 344-349, 2024 01 12.
Article en En | MEDLINE | ID: mdl-38147593
ABSTRACT
In this study, we present a nickel-catalyzed reductive C(sp3)-Sb coupling of unactivated alkyl chlorides with chlorostibines. This approach is highly versatile, tolerating various functional groups such as acetal, alkene, nitrile, amine, ester, silyl ether, thioether, and various heterocyclic compounds. Notably, the late-stage modification of bioactive molecules and the satisfactory anticancer activity against cancerous MDA-MB-231 also demonstrate the potential application.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cloruros / Níquel Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cloruros / Níquel Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article