Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023.
Thorac Cardiovasc Surg
; 72(4): 273-284, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38154473
ABSTRACT
This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Trasplante de Corazón
/
Xenoinjertos
/
Supervivencia de Injerto
/
Inmunosupresores
Límite:
Animals
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Thorac Cardiovasc Surg
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania