Your browser doesn't support javascript.
loading
Clinicopathologic Characterization of Lymphocytic Colitis in the Pediatric Population.
González, Iván A; Conrad, Maire; Weinbrom, Sarah; Patel, Trusha; Kelsen, Judith R; Russo, Pierre.
Afiliación
  • González IA; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Conrad M; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, PA, USA.
  • Weinbrom S; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, PA, USA.
  • Patel T; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, PA, USA.
  • Kelsen JR; Department of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, PA, USA.
  • Russo P; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, PA, USA.
Pediatr Dev Pathol ; 27(2): 156-168, 2024.
Article en En | MEDLINE | ID: mdl-38160439
ABSTRACT

BACKGROUND:

Lymphocytic colitis (LC) in the pediatric population has been associated with immune dysregulation.

METHODS:

Single-center retrospective study of pediatric LC.

RESULTS:

50 patients (35 female, 70%) with a median age of 12 years at diagnosis (interquartile range 5.7-15.8) of LC were identified. At presentation, 11 patients (22%) had malnutrition, 16 (32%) had a known underlying immune dysregulation, 4 (8%) had celiac disease (CD), and none had a diagnosis of inflammatory bowel disease. The most common medications prior to diagnosis were non-steroidal anti-inflammatory drugs, proton pump inhibitor, and selective serotonin reuptake inhibitors (10% each). Colonic biopsies showed a median number of intraepithelial lymphocytes (IELs)/100 epithelial cells of 48 (range 25-85), and only 10% of cases had neutrophilic cryptitis. Upper gastrointestinal tract findings included lymphocytic esophagitis (4%), and duodenal IELs without and with villous blunting (9% each) (n 47). Ten patients (23%) had increased IELs in the terminal ileum (n 43). Treatments including 5-ASA, budesonide, prednisone, and gluten-free diet improved symptoms in <50% of patients (n 42), and all follow-up colonoscopies showed persistent LC (n 13).

CONCLUSION:

Our study supports the association of LC with immune-mediated conditions, most commonly celiac disease. Symptomatic improvement was seen in <50% of patients with none of the patients with repeat colonoscopy showing histologic improvement.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Enfermedad Celíaca / Colitis Linfocítica Límite: Child / Female / Humans Idioma: En Revista: Pediatr Dev Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Enfermedad Celíaca / Colitis Linfocítica Límite: Child / Female / Humans Idioma: En Revista: Pediatr Dev Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos