Understanding Factors that Influence Prognosis and Response to Therapy in Clear Cell Renal Cell Carcinoma.
Adv Anat Pathol
; 31(2): 96-104, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38179997
ABSTRACT
In this review, we highlight and contextualize emerging morphologic prognostic and predictive factors in renal cell carcinoma. We focus on clear cell renal cell carcinoma (ccRCC), the most common histologic subtype. Our understanding of the molecular characterization of ccRCC has dramatically improved in the last decade. Herein, we highlight how these discoveries have laid the foundation for new approaches to prognosis and therapeutic decision-making for patients with ccRCC. We explore the clinical relevance of common mutations, established gene expression signatures, intratumoral heterogeneity, sarcomatoid/rhabdoid morphology and PD-L1 expression, and discuss their impact on predicting response to therapy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Renales
/
Neoplasias Renales
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Adv Anat Pathol
Asunto de la revista:
ANATOMIA
/
PATOLOGIA
Año:
2024
Tipo del documento:
Article