A comprehensive and visualized analysis of relationship between ferroptosis and tumor using bibliometrics and bioinformatics.

ABSTRACT

This study aimed to summarize the current developments and hub genes in the ferroptosis field using bibliometrics and bioinformatics and provide guidance for future developments. The publications on ferroptosis from 2012 to 2021 were extracted from the Web of Science database. VOSviewer software and CiteSpace software were used to visualize and predict the trend of ferroptosis research. The key genes related to ferroptosis were selected from the Web of Genecards, and Kyoto Encyclopedia of Genes and Genomes (KEGG)/Gene Ontology (GO) analysis was performed. Cytoscape software and online survival curve analysis platform were also used to screen hub genes and analyze their roles. Chinese researchers published the highest number of publications in this field, while American publications exhibited higher quality. In terms of institutions, Central South University and Zhejiang University have the highest number of publications. Cell Death Disease published more studies than other journals. The application of ferroptosis is a major research area, and, importantly, "RCD", "FTH1", and "nomogram" are the keywords. We also found tumor-related pathways of interest in the field of ferroptosis. Sirtuin 3 (SIRT3), Glutathione Peroxidase 4 (GPX4), and transferrin receptor (TFRC) genes were of significance for the prognosis of tumors. The number of publications on ferroptosis may increase in the future. Cooperation among countries and disciplines is particularly important in this regard. Also, the applications of ferroptosis, especially in chemotherapy and immunotherapy for tumors, will be the focus of future research. Keywords "RCD", "FTH1", and "nomogram" is receiving high attention, and in-depth studies on tumor-related genes SIRT3, GPX4, and TFRC may provide new therapeutic targets.