Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Diabetes Care
; 47(4): 589-593, 2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-38252886
ABSTRACT
OBJECTIVE:
We report mortality outcomes in the Glycemia Reduction Approaches in Diabetes A Comparative Effectiveness Study (GRADE) among people with type 2 diabetes diagnosed within 10 years and no recent history of cardiovascular events or cancer. RESEARCH DESIGN ANDMETHODS:
Overall mortality rates and major causes of death were assessed over an average of 5 years of follow-up. Cause of death was adjudicated centrally by a committee masked to treatment assignment. We examined baseline covariates and the 10-year Framingham Risk Score for associations.RESULTS:
Mortality rate was low (0.59 per 100 participant-years). Participants who died during follow-up were likely to be older, be male, have a history of hypertension, have a history of smoking, and have moderate albuminuria. The two most common underlying causes of death were "cardiovascular-cause" (a composite of underlying causes) (38.6%) and cancer (26.8%). There were no differences by treatment group.CONCLUSIONS:
Among people with diabetes of relatively short duration, cause of death was varied. Attention to health risks beyond cardiovascular diseases is warranted.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Diabetes Mellitus Tipo 2
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Hipertensión
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Neoplasias
Límite:
Humans
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Male
Idioma:
En
Revista:
Diabetes Care
Año:
2024
Tipo del documento:
Article