Heteropolyacid-Catalyzed Phosphorylation of Secondary Aromatic Alcohols with H-Phosphine Oxides in DMC: A Simple Protocol for C-P Bond Formation.
J Org Chem
; 89(4): 2397-2407, 2024 Feb 16.
Article
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| MEDLINE
| ID: mdl-38275252
ABSTRACT
We successfully achieved the phosphorylation of secondary aromatic alcohols with H-phosphine oxides (less developed system) using phosphotungstic acid as a catalyst in dimethyl carbonate. The system was simple and environmentally friendly and showed better activity than traditional Lewis or Brønsted acids such as FeCl3, p-TsOH·H2O, etc., generating up to a 97% isolated yield. Control experiments indicated that the reaction did not occur through the radical pathway, and ethers and carbocation were the key intermediates in the pathway.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
China