Aneuploidy and complex genomic rearrangements in cancer evolution.
Nat Cancer
; 5(2): 228-239, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38286829
ABSTRACT
Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aberraciones Cromosómicas
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Nat Cancer
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido