A novel pH-activated AIEgen probe for dynamic lysosome tracking and high-efficiency photodynamic therapy.

Hu, Yingcai; Yin, Sheng-Yan; Deng, Ting; Li, Jishan

Hu, Yingcai; Yin, Sheng-Yan; Deng, Ting; Li, Jishan.

Afiliación

Hu Y; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. jishanli@hnu.edu.cn.
Yin SY; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. jishanli@hnu.edu.cn.
Deng T; Institute of Applied Chemistry, School of Science, Central South University of Forestry and Technology, Changsha 410004, China. muzi_dt@hotmail.com.
Li J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. jishanli@hnu.edu.cn.

Chem Commun (Camb) ; 60(22): 3047-3050, 2024 Mar 12.

Article en En | MEDLINE | ID: mdl-38376492

ABSTRACT

ABSTRACT

A novel AIEgen molecular probe (N-3QL) with typical AIE effects, good biocompatibility, lysosome targeting, pH activation, excellent photostability, and high brightness was synthesized using two simple synthetic steps. Spectroscopic and cytotoxicity experiments indicate that N-3QL can not only be used for the dynamic monitoring of cancer cell lysosomes, but also for photodynamic therapy (PDT) ablation of cancer cells.

Asunto(s)

Fotoquimioterapia; Fotoquimioterapia/métodos; Sondas Moleculares/análisis; Concentración de Iones de Hidrógeno; Lisosomas/química

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China

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