Characteristics and drivers of fatigue in patients with psoriasis and psoriatic arthritis: A cross sectional study.
J Am Acad Dermatol
; 91(1): 57-63, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38395230
ABSTRACT
BACKGROUND:
A multitude of factors may influence fatigue in psoriasis and psoriatic arthritis (PsA); however, their individual fatigue components have not been thoroughly examined.OBJECTIVES:
To explore characteristics of fatigue and its potential drivers in a cohort of patients with psoriasis with or without PsA.METHODS:
Adults with psoriasis and a nonpsoriasis control group completed the Multidimensional Fatigue Inventory-20 questionnaire. Patients with psoriasis also reported joint pain intensity, pruritus, skin pain, and sleep problems using a numerical rating scale. Linear regression models were applied to continuous outcomes, and beta coefficients (ß) for the slopes were estimated with 95% confidence intervals (CIs).RESULTS:
Among 2741 adults with psoriasis (of which 593 also had PsA) and 3788 controls, the impact on total fatigue was greatest for PsA (ß = 5.22; 95% CI, 3.55-6.90), followed by psoriasis (ß = 2.10; 95% CI, 0.96-3.25), compared with the general population (Ptrend < .0001). Among patients with psoriasis with or without PsA, increasing joint pain intensity was associated with overall fatigue (ß = 2.23 [95% CI, 2.03-2.44] for each 1-point increase in joint pain numerical rating scale score).LIMITATIONS:
We lacked information on the effect of pharmacotherapy.CONCLUSIONS:
These findings highlight the importance of a symptom-based approach when treating psoriasis, rather than focusing on objective severity measures alone.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Índice de Severidad de la Enfermedad
/
Artritis Psoriásica
/
Fatiga
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca