Disrupted TGF-ß signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells.
J Clin Invest
; 134(6)2024 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-38488005
ABSTRACT
Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of AT1 cells, which constitute a majority of the alveolar surface area. In this issue of the JCI, Callaway and colleagues explored the role of TGF-ß signaling in AT1 cells for managing the AT1-to-AT2 transition and its involvement in the integration of mechanical forces with the pulmonary matrisome during development. The findings implicate AT1 cells in the pathogenesis of BPD.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Displasia Broncopulmonar
Límite:
Animals
/
Humans
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Infant
/
Newborn
Idioma:
En
Revista:
J Clin Invest
Año:
2024
Tipo del documento:
Article