Long-term prognosis analysis of surgical therapy for bilateral synchronous multiple primary lung cancer: a follow-up of 293 cases.
J Thorac Dis
; 16(2): 1450-1462, 2024 Feb 29.
Article
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| MEDLINE
| ID: mdl-38505060
ABSTRACT
Background:
Bilateral synchronous multiple primary lung cancer (BSMPLC) presents significant clinical challenges due to its unique characteristics and prognosis. Understanding the risk factors that influence overall survival (OS) and recurrence-free survival (RFS) is crucial for optimizing therapeutic strategies for BSMPLC patients.Methods:
We retrospectively analyzed clinical characteristics and treatment outcomes of 293 patients with BSMPLC who underwent surgical treatment between January 2010 and July 2017.Results:
The 10-year OS and RFS rates were 96.1% and 92.8%, respectively. Preoperative forced expiratory volume in 1 second (FEV1) ≥70% [hazard ratio (HR), 0.214; 95% confidence interval (CI) 0.053 to 0.857], identical pathology types (HR, 9.726; 95% CI 1.886 to 50.151), largest pT1 (HR, 7.123; 95% CI 2.663 to 19.055), and absence of lymphovascular invasion (LVI; HR, 7.021; 95% CI 1.448 to 34.032) emerged as independent predictors of improved OS. Moreover, the sum of tumor sizes less than or equal to 3 cm (HR, 6.229; 95% CI 1.411 to 27.502) and absence of pleural invasion (HR, 3.442; 95% CI 1.352 to 8.759) were identified as independent predictors of enhanced RFS. The presence or absence of residual nodules after bilateral surgery did not influence patients' OS (P=0.987) and RFS (P=0.054).Conclusions:
Patients with BSMPLC who underwent surgery generally had a favorable prognosis. Whether or not to remove all nodules bilaterally does not affect the patient's long-term prognosis, suggesting the need for an individualized surgical approach.
Texto completo:
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Thorac Dis
Año:
2024
Tipo del documento:
Article
País de afiliación:
China