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Superagers Resist Typical Age-Related White Matter Structural Changes.
Garo-Pascual, Marta; Zhang, Linda; Valentí-Soler, Meritxell; Strange, Bryan A.
Afiliación
  • Garo-Pascual M; Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid 28223, Spain marta.garo@ctb.upm.es bryan.strange@upm.es.
  • Zhang L; Alzheimer Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Centre, Madrid 28031, Spain.
  • Valentí-Soler M; PhD Program in Neuroscience, Autonomous University of Madrid-Cajal Institute, Madrid 28029, Spain.
  • Strange BA; Alzheimer Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Centre, Madrid 28031, Spain.
J Neurosci ; 44(25)2024 Jun 19.
Article en En | MEDLINE | ID: mdl-38684365
ABSTRACT
Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable. In a sample of 64 superagers (mean age, 81.9; 59% women) and 55 typical older adults (mean age, 82.4; 64% women) from the Vallecas Project, we studied, cross-sectionally and longitudinally over 5 years with yearly follow-ups, the global cerebral white matter status as well as region-specific white matter microstructure assessment derived from diffusivity measures. Superagers and typical older adults showed no difference in global white matter health (total white matter volume, Fazekas score, and lesions volume) cross-sectionally or longitudinally. However, analyses of diffusion parameters revealed the better white matter microstructure in superagers than in typical older adults. Cross-sectional differences showed higher fractional anisotropy (FA) in superagers mostly in frontal fibers and lower mean diffusivity (MD) in most white matter tracts, expressed as an anteroposterior gradient with greater group differences in anterior tracts. FA decrease over time is slower in superagers than in typical older adults in all white matter tracts assessed, which is mirrored by MD increases over time being slower in superagers than in typical older adults in all white matter tracts except for the corticospinal tract, the uncinate fasciculus, and the forceps minor. The better preservation of white matter microstructure in superagers relative to typical older adults supports resistance to age-related brain structural changes as a mechanism underpinning the remarkable memory capacity of superagers, while their regional aging pattern is in line with the last-in-first-out hypothesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Sustancia Blanca Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Sustancia Blanca Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article