Long-Term Efficacy of Tildrakizumab in the Treatment of Psoriasis.
Skin Therapy Lett
; 29(3): 5-8, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38781953
ABSTRACT
The pathogenesis of psoriasis has been linked to autoimmune and autoinflammatory traits that result in atypical cytokine and keratinocyte activation and proliferation. Many cytokine pathways are involved in the development of inflammation with interleukin-23 (IL-23) playing a significant role in plaque-type psoriasis. Biologic agents that target specific cytokines have shown to be effective therapies in the treatment of plaque-type psoriasis over other conventional treatments such as systemic retinoids. Tildrakizumab is an immunoglobulin G1-kappa monoclonal antibody that inhibits the IL-23/IL-17 pathway and has demonstrated through two three-part randomized Phase 3 clinical trials (reSURFACE 1 and reSURFACE 2) and their extension trials to be an efficacious and safe therapy for the targeted treatment of moderate-to-severe plaque-type psoriasis.
Palabras clave
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Anticuerpos Monoclonales Humanizados
/
Anticuerpos Monoclonales
Límite:
Humans
Idioma:
En
Revista:
Skin Therapy Lett
Asunto de la revista:
DERMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá