Efficacy and safety of pulsed field ablation for accessory pathways: a pilot study.
Europace
; 26(7)2024 Jul 02.
Article
en En
| MEDLINE
| ID: mdl-38801673
ABSTRACT
AIMS:
Radiofrequency ablation is used as a first-line therapy for accessory pathways (APs). However, data regarding the effects of pulsed field ablation (PFA) on APs are limited. We sought to evaluate the acute procedural and 6-month success and safety of PFA in a cohort of patients with APs. METHODS ANDRESULTS:
A focal contact force-sensing PFA catheter was used for patients with APs. Pulsed field ablation generator generated a bipolar and biphasic waveform (±1000â V) with a duration of 100â ms from the tip of the PFA catheter. A 100% acute procedural success was achieved in 10 conscious patients with APs (7 left anterolateral, 2 left inferolateral, and 1 right posteroseptal APs) including 6 (60%) patients after an initial application. The average total ablation time was 6.3 ± 4.9â s for 4.7 ± 1.8 ablation sites (ASs), including 3.1 ± 2.4â s at targets and 3.2 ± 2.9â s at 3.2 ± 2 bolus ASs. The mean skin-to-skin time was 59.3 ± 15.5â min, and PFA catheter dwell time was 29.4 ± 7.8â min. One patient encountered transient sinus arrest during PFA due to parasympathetic overexcitation. Sinus rhythm was restored in all patients without any significant adverse events during the short-term follow-up.CONCLUSION:
Pulsed field ablation of APs was feasible, effective, and safe. Its efficiency was remarkable for its ultrarapid termination of AP conduction. Further studies are warranted to prove whether utilization of PFA with current parameters can extend to manifold AP ablation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Taquicardia Ventricular
/
Ablación por Catéter
/
Fascículo Atrioventricular Accesorio
/
Ablación por Radiofrecuencia
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Europace
Asunto de la revista:
CARDIOLOGIA
/
FISIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China