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Generalized cue reactivity in dopamine neurons after opioids.
Lehmann, Collin M; Miller, Nora E; Nair, Varun S; Costa, Kauê M; Schoenbaum, Geoffrey; Moussawi, Khaled.
Afiliación
  • Lehmann CM; Department of Psychiatry, University of Pittsburgh; Pittsburgh, 15219, USA.
  • Miller NE; Department of Psychiatry, University of Pittsburgh; Pittsburgh, 15219, USA.
  • Nair VS; Department of Psychiatry, University of Pittsburgh; Pittsburgh, 15219, USA.
  • Costa KM; Department of Psychology, University of Alabama at Birmingham; Birmingham, 35233, USA.
  • Schoenbaum G; National Institute on Drug Abuse, National Institutes of Health; Baltimore, 21224, USA.
  • Moussawi K; Department of Psychiatry, University of Pittsburgh; Pittsburgh, 15219, USA.
bioRxiv ; 2024 Jun 02.
Article en En | MEDLINE | ID: mdl-38853878
ABSTRACT
Cue reactivity is the maladaptive neurobiological and behavioral response upon exposure to drug cues and is a major driver of relapse. The leading hypothesis is that dopamine release by addictive drugs represents a persistently positive reward prediction error that causes runaway enhancement of dopamine responses to drug cues, leading to their pathological overvaluation compared to non-drug reward alternatives. However, this hypothesis has not been directly tested. Here we developed Pavlovian and operant procedures to measure firing responses, within the same dopamine neurons, to drug versus natural reward cues, which we found to be similarly enhanced compared to cues predicting natural rewards in drug-naïve controls. This enhancement was associated with increased behavioral reactivity to the drug cue, suggesting that dopamine release is still critical to cue reactivity, albeit not as previously hypothesized. These results challenge the prevailing hypothesis of cue reactivity, warranting new models of dopaminergic function in drug addiction, and provide critical insights into the neurobiology of cue reactivity with potential implications for relapse prevention.

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos