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Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.
Peterson, Amalia; Sathe, Aditi; Zaras, Dimitrios; Yang, Yisu; Durant, Alaina; Deters, Kacie D; Shashikumar, Niranjana; Pechman, Kimberly R; Kim, Michael E; Gao, Chenyu; Khairi, Nazirah Mohd; Li, Zhiyuan; Yao, Tianyuan; Huo, Yuankai; Dumitrescu, Logan; Gifford, Katherine A; Wilson, Jo Ellen; Cambronero, Francis; Risacher, Shannon L; Beason-Held, Lori L; An, Yang; Arfanakis, Konstantinos; Erus, Guray; Davatzikos, Christos; Tosun, Duygu; Toga, Arthur W; Thompson, Paul M; Mormino, Elizabeth C; Zhang, Panpan; Schilling, Kurt; Albert, Marilyn; Kukull, Walter; Biber, Sarah A; Landman, Bennett A; Johnson, Sterling C; Schneider, Julie; Barnes, Lisa L; Bennett, David A; Jefferson, Angela L; Resnick, Susan M; Saykin, Andrew J; Hohman, Timothy J; Archer, Derek B.
Afiliación
  • Peterson A; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Sathe A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.
  • Zaras D; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Yang Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Durant A; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Deters KD; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Shashikumar N; Department of Integrative Biology and Physiology, University of California, Los Angeles.
  • Pechman KR; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Kim ME; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Gao C; Department of Computer Science, Vanderbilt University, Nashville, TN.
  • Khairi NM; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN.
  • Li Z; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN.
  • Yao T; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN.
  • Huo Y; Department of Computer Science, Vanderbilt University, Nashville, TN.
  • Dumitrescu L; Department of Computer Science, Vanderbilt University, Nashville, TN.
  • Gifford KA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN.
  • Wilson JE; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Cambronero F; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.
  • Risacher SL; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN.
  • Beason-Held LL; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN.
  • An Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Arfanakis K; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.
  • Erus G; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Davatzikos C; Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
  • Tosun D; Veteran's Affairs, Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System.
  • Toga AW; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Thompson PM; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.
  • Mormino EC; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN.
  • Zhang P; Laboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD.
  • Schilling K; Laboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD.
  • Albert M; Department of Radiology, University of Pennsylvania, Philadelphia, PA.
  • Kukull W; Department of Radiology, University of Pennsylvania, Philadelphia, PA.
  • Biber SA; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
  • Landman BA; Laboratory of Neuroimaging, USC Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
  • Johnson SC; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA.
  • Schneider J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
  • Barnes LL; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Bennett DA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
  • Jefferson AL; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN2.
  • Resnick SM; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN.
bioRxiv ; 2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38915636
ABSTRACT

INTRODUCTION:

The effects of sex, race, and Apolipoprotein E (APOE) - Alzheimer's disease (AD) risk factors - on white matter integrity are not well characterized.

METHODS:

Diffusion MRI data from nine well-established longitudinal cohorts of aging were free-water (FW)-corrected and harmonized. This dataset included 4,702 participants (age=73.06 ± 9.75) with 9,671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex, race, and APOE-ε4 carrier status.

RESULTS:

Sex differences in FAFWcorr in association and projection tracts, racial differences in FAFWcorr in projection tracts, and APOE-ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced.

DISCUSSION:

There are prominent differences in white matter microstructure by sex, race, and APOE-ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article