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Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects.
Shen, Ting; Sheriff, Samran; You, Yuyi; Jiang, Jiyang; Schulz, Angela; Francis, Heather; Mirzaei, Mehdi; Saks, Danit; Palanivel, Viswanthram; Basavarajappa, Devaraj; Chitranshi, Nitin; Gupta, Veer; Wen, Wei; Sachdev, Perminder S; Jia, Huixun; Sun, Xiaodong; Graham, Stuart L; Gupta, Vivek K.
Afiliación
  • Shen T; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai
  • Sheriff S; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • You Y; Save Sight Institute, The University of Sydney, Sydney, NSW 2000, Australia.
  • Jiang J; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Schulz A; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Francis H; Save Sight Institute, The University of Sydney, Sydney, NSW 2000, Australia.
  • Mirzaei M; Centre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
  • Saks D; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Palanivel V; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Basavarajappa D; Neurology Department, Royal North Shore Hospital, St Leonards NSW 2065, Australia.
  • Chitranshi N; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Gupta V; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Wen W; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Sachdev PS; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Jia H; Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
  • Sun X; Faculty of Health, Deakin University, VIC 3125, Australia.
  • Graham SL; Centre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
  • Gupta VK; Centre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Aging Dis ; 15(5): 2315-2327, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-38916728
ABSTRACT
Aging is associated with progressive brain atrophy and declines in learning and memory, often attributed to hippocampal or cortical deterioration. The role of brain-derived neurotrophic factor (BDNF) in modulating the structural and functional changes in the brain and visual system, particularly in relation to BDNF Val66Met polymorphism, remains underexplored. In this present cross-sectional observational study, we aimed to assess the effects of BDNF polymorphism on brain structural integrity, cognitive function, and visual pathway alterations. A total of 108 older individuals with no evidence of dementia and a mean (SD) age of 67.3 (9.1) years were recruited from the Optic Nerve Decline and Cognitive Change (ONDCC) study cohort. The BDNF Met allele carriage had a significant association with lower entorhinal cortex volume (6.7% lower compared to the Val/Val genotype, P = 0.02) and posterior cingulate volume (3.2% lower than the Val/Val group, P = 0.03), after adjusting for confounding factors including age, sex and estimated total intracranial volumes (eTIV). No significant associations were identified between the BDNF Val66Met genotype and other brain volumetric or diffusion measures, cognitive performances, or vision parameters except for temporal retinal nerve fibre layer thickness. Small but significant correlations were found between visual structural and functional, cognitive, and brain morphological metrics. Our findings suggest that carriage of BDNF Val66Met polymorphism is associated with lower entorhinal cortex and posterior cingulate volumes and may be involved in modulating the cortical morphology along the aging process.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor Neurotrófico Derivado del Encéfalo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Aging Dis Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor Neurotrófico Derivado del Encéfalo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Aging Dis Año: 2024 Tipo del documento: Article