Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Meta-Analysis of Randomized Controlled Trials and Trial Sequential Analysis.
Diagnostics (Basel)
; 14(12)2024 Jun 12.
Article
en En
| MEDLINE
| ID: mdl-38928653
ABSTRACT
BACKGROUND:
The efficacy of endoscopic ultrasound-guided liver biopsy (EUS-LB) compared to percutaneous liver biopsy (PC-LB) remains uncertain.METHODS:
Our data consist of randomized controlled trials (RCTs) comparing EUS-LB to PC-LB, found through a literature search via PubMed/Medline and Embase. The primary outcome was sample adequacy, whereas secondary outcomes were longest and total lengths of tissue specimens, diagnostic accuracy, and number of complete portal tracts (CPTs).RESULTS:
Sample adequacy did not significantly differ between EUS-LB and PC-LB (risk ratio [RR] 1.18; 95% confidence interval [CI] 0.58-2.38; p = 0.65), with very low evidence quality and inadequate sample size as per trial sequential analysis (TSA). The two techniques were equivalent with respect to diagnostic accuracy (RR 1; CI 0.95-1.05; p = 0.88), mean number of complete portal tracts (mean difference 2.29, -4.08 to 8.66; p = 0.48), and total specimen length (mean difference -0.51, -20.92 to 19.9; p = 0.96). The mean maximum specimen length was significantly longer in the PC-LB group (mean difference -3.11, -5.51 to -0.71; p = 0.01), and TSA showed that the required information size was reached.CONCLUSION:
EUS-LB and PC-LB are comparable in terms of diagnostic performance although PC-LB provides longer non-fragmented specimens.
Texto completo:
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Diagnostics (Basel)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido