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Large-scale production of extracellular vesicles: Report on the "massivEVs" ISEV workshop.
Paolini, Lucia; Monguió-Tortajada, Marta; Costa, Marta; Antenucci, Fabio; Barilani, Mario; Clos-Sansalvador, Marta; Andrade, André Cronemberger; Driedonks, Tom A P; Giancaterino, Sara; Kronstadt, Stephanie M; Mizenko, Rachel R; Nawaz, Muhammad; Osteikoetxea, Xabier; Pereira, Carla; Shrivastava, Surya; Boysen, Anders Toftegaard; van de Wakker, Simonides Immanuel; van Herwijnen, Martijn J C; Wang, Xiaoqin; Watson, Dionysios C; Gimona, Mario; Kaparakis-Liaskos, Maria; Konstantinov, Konstantin; Lim, Sai Kiang; Meisner-Kober, Nicole; Stork, Michiel; Nejsum, Peter; Radeghieri, Annalisa; Rohde, Eva; Touzet, Nicolas; Wauben, Marca H M; Witwer, Kenneth W; Bongiovanni, Antonella; Bergese, Paolo.
Afiliación
  • Paolini L; Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
  • Monguió-Tortajada M; Center for Colloid and Surface Science (CSGI) Department of Chemistry University of Florence Sesto Fiorentino (FI) Italy.
  • Costa M; Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy.
  • Antenucci F; CREC Research Program Health Science Research Institute Germans Trias i Pujol (IGTP) Badalona Spain.
  • Barilani M; Heart Institute (iCor) Cardiology Department Germans Trias i Pujol University Hospital Badalona Spain.
  • Clos-Sansalvador M; iBET Instituto de Biologia Experimental e Tecnológica Oeiras Portugal.
  • Andrade AC; Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de Lisboa Oeiras Portugal.
  • Driedonks TAP; Department of Veterinary and Animal Sciences University of Copenhagen Copenhagen Denmark.
  • Giancaterino S; Laboratory of Regenerative Medicine ‒ Cell Factory Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy.
  • Kronstadt SM; REMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department University Hospital Germans Trias i Pujol (HUGTiP) Badalona (Barcelona) Catalonia Spain.
  • Mizenko RR; Department of Cell Biology Physiology and Immunology Universitat Autònoma de Barcelona (UAB) Bellaterra Spain.
  • Nawaz M; Experimental and Clinical Cell Therapy Institute (ExCT) Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Salzburg Austria.
  • Osteikoetxea X; CDL Research University Medical Center Utrecht Utrecht University Utrecht The Netherlands.
  • Pereira C; Department of Molecular and Comparative Pathology Johns Hopkins School of Medicine Baltimore Maryland USA.
  • Shrivastava S; Department of Civil Chemical Environmental and Materials Engineering Alma Mater Studiorum University of Bologna Bologna Italy.
  • Boysen AT; Fischell Department of Bioengineering University of Maryland College Park Maryland USA.
  • van de Wakker SI; Department of Biomedical Engineering University of California Davis California USA.
  • van Herwijnen MJC; Department of Rheumatology and Inflammation Research Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
  • Wang X; HCEMM-SU Extracellular Vesicles Research Group Budapest Hungary.
  • Watson DC; Department of Genetics Cell- and Immunobiology Semmelweis University Budapest Hungary.
  • Gimona M; Exogenus Therapeutics S.A. Cantanhede Portugal.
  • Kaparakis-Liaskos M; Center for Gene Therapy City of Hope Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute at the City of Hope Duarte California USA.
  • Konstantinov K; Department of Clinical Medicine Aarhus University Aarhus Denmark.
  • Lim SK; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark.
  • Meisner-Kober N; Department of Cardiology Experimental Cardiology Laboratory University Medical Center Utrecht Utrecht University Utrecht The Netherlands.
  • Stork M; Department of Biomolecular Health Sciences Faculty of Veterinary Medicine Utrecht University Utrecht Netherlands.
  • Nejsum P; Discovery Biology Discovery Sciences BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden.
  • Radeghieri A; University Hospitals Cleveland Medical Center Cleveland Ohio USA.
  • Rohde E; Case Western Reserve University Cleveland Ohio USA.
  • Touzet N; Cleveland Clinic Cleveland Ohio USA.
  • Wauben MHM; GMP Unit Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS) Paracelsus Medical University Salzburg Austria.
  • Witwer KW; Research Program "Nanovesicular Therapies" Paracelsus Medical University Salzburg Austria.
  • Bongiovanni A; Transfer Centre for Extracellular Vesicle Theralytic Technologies (EV-TT) Salzburg Austria.
  • Bergese P; Department of Microbiology, Anatomy, Physiology and Pharmacology La Trobe University Melbourne Victoria Australia.
J Extracell Biol ; 1(10): e63, 2022 Oct.
Article en En | MEDLINE | ID: mdl-38939213
ABSTRACT
Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, "The Extracellular Vesicle Foundry" (evFOUNDRY) and "Extracellular vesicles from a natural source for tailor-made nanomaterials" (VES4US), organized a workshop entitled "massivEVs" to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during "massivEVs", the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Extracell Biol Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Extracell Biol Año: 2022 Tipo del documento: Article