High-throughput kinetics in drug discovery.
SLAS Discov
; 29(5): 100170, 2024 Jul 03.
Article
en En
| MEDLINE
| ID: mdl-38964171
ABSTRACT
The importance of a drug's kinetic profile and interplay of structure-kinetic activity with PK/PD has long been appreciated in drug discovery. However, technical challenges have often limited detailed kinetic characterization of compounds to the latter stages of projects. This review highlights the advances that have been made in recent years in techniques, instrumentation, and data analysis to increase the throughput of detailed kinetic and mechanistic characterization, enabling its application earlier in the drug discovery process.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
SLAS Discov
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido