Simple dynamic cell culture system reduces recording noise in microelectrode array recordings.
MRS Commun
; 14(3): 261-266, 2024.
Article
en En
| MEDLINE
| ID: mdl-38966401
ABSTRACT
Microelectrode arrays (MEAs) have applications in drug discovery, toxicology, and basic research. They measure the electrophysiological response of tissue cultures to quantify changes upon exposure to biochemical stimuli. Unfortunately, manual addition of chemicals introduces significant noise in the recordings. Here, we report a simple-to-fabricate fluidic system that addresses this issue. We show that cell cultures can be successfully established in the fluidic compartment under continuous flow conditions and that the addition of chemicals introduces minimal noise in the recordings. This dynamic cell culture system represents an improvement over traditional tissue culture wells used in MEAs, facilitating electrophysiology measurements.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
MRS Commun
Año:
2024
Tipo del documento:
Article