Immune Dysfunction in Schizophrenia Spectrum Disorders.
Annu Rev Clin Psychol
; 20(1): 229-257, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38996077
ABSTRACT
Evidence from epidemiological, clinical, and biological research resulted in the immune hypothesis:
the hypothesis that immune system dysfunction is involved in the pathophysiology of schizophrenia spectrum disorders (SSD). The promising implication of this hypothesis is the potential to use existing immunomodulatory treatment for innovative interventions for SSD. Here, we provide a selective historical review of important discoveries that have shaped our understanding of immune dysfunction in SSD. We first explain the basic principles of immune dysfunction, after which we travel more than a century back in time. Starting our journey with neurosyphilis-associated psychosis in the nineteenth century, we continue by evaluating the role of infections and autoimmunity in SSD and findings from assessment of immune function using new techniques, such as cytokine levels, microglia density, neuroimaging, and gene expression. Drawing from these findings, we discuss anti-inflammatory interventions for SSD, and we conclude with a look into the future.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Clin Psychol
Asunto de la revista:
PSICOLOGIA
Año:
2024
Tipo del documento:
Article