The role of galectins in the regulation of autophagy and inflammasome in host immunity.
Semin Immunopathol
; 46(3-4): 6, 2024 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-39042263
ABSTRACT
Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or "self"), originating from damaged endocytic vesicles, or exogenous (or "non-self"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Galectinas
/
Inflamasomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Immunopathol
/
Semin. immunopathol
/
Seminars in immunopathology
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Taiwán