Generation of two iPSC lines from dilated cardiomyopathy patients with pathogenic variants in the SCN5A gene.
Stem Cell Res
; 80: 103498, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39067410
ABSTRACT
Dilated cardiomyopathy (DCM) is a disorder of cardiac ventricular dilation and contractile dysfunction that often progresses to heart failure. Multiple genes have been associated with DCM, including SCN5A which has been linked to 2 % of all DCM cases. Peripheral mononuclear blood cells from DCM patients with SCN5A variants (c.2440C>T and c.665G>A) were utilized to generate two human induced pluripotent stem cell (iPSC) lines. Both lines exhibited typical iPSC morphology, expressed pluripotency markers, normal karyotypes, and trilineage differentiation capabilities. These lines offer valuable resources for investigating the mechanism of SCN5A-associated DCM, facilitating studies of ion channel protein involvement in the disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Dilatada
/
Células Madre Pluripotentes Inducidas
/
Canal de Sodio Activado por Voltaje NAV1.5
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Stem Cell Res
/
Stem cell research (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos