Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
J Clin Invest
; 76(6): 2066-9, 1985 Dec.
Article
en En
| MEDLINE
| ID: mdl-3935667
ABSTRACT
The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Interferón gamma
/
Interleucina-2
/
Leishmaniasis Visceral
Límite:
Humans
Idioma:
En
Revista:
J Clin Invest
Año:
1985
Tipo del documento:
Article