The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro.
Br J Pharmacol
; 49(2): 361-3, 1973 Oct.
Article
en En
| MEDLINE
| ID: mdl-4152220
ABSTRACT
Burimamide, an H(2)-receptor blocking agent, has been shown capable of blocking the uptake and metabolism of [(14)C]-histamine, both in the guinea-pig isolated atrium and in murine neoplastic mast cells. This occurs even at concentrations far below the dose range capable of blocking the positive chronotropic effect of histamine in the isolated atrium. In the atrium, very low concentrations of burimamide were found capable of blocking histamine metabolism.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tiourea
/
Histamina
/
Antagonistas de los Receptores Histamínicos H1
/
Mastocitos
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Año:
1973
Tipo del documento:
Article