Mutagenicity of N-nitroso pyridinol carbamate with the Salmonella/mammalian microsome test.
Cancer Lett
; 7(2-3): 135-9, 1979 Jul.
Article
en En
| MEDLINE
| ID: mdl-476608
ABSTRACT
Pyridinol carbamate was nitrosated to the N,N1-dinitroso derivative and the structure was proved by spectroscopic methods, including chemical ionization mass spectroscopy. By the Ames test, the dinitroso derivative showed a significant dose-dependent mutagenic response with Salmonella typhimurium strains TA 1535 and TA 100; the response became more pronounced in the presence of microsomes. As the dosage of N-nitroso pyridinol carbamate increased, the number of revertant colonies also increased. Pyridinol carbamate was not mutagenic.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinolcarbamato
/
Carbamatos
/
Mutágenos
/
Nitrosaminas
Límite:
Animals
Idioma:
En
Revista:
Cancer Lett
Año:
1979
Tipo del documento:
Article