Tricyclic antidepressants: plasma levels and clinical findings in overdose.
Am J Psychiatry
; 135(11): 1325-8, 1978 Nov.
Article
en En
| MEDLINE
| ID: mdl-707629
ABSTRACT
Following amitriptyline or imipramine overdose by 30 patients, total plasma concentrations ranged from 29 to 1732 ng/ml but did not correlate well with physical findings or most electrocardiographic changes. Only those patients with a QRS interval greater than 0.1 second had significantly elevated plasma levels. However, a plasma level ratio of the parent drug (amitriptyline, imipramine) to its respective N-desmethyl metabolite (nortriptyline, desmethylimipramine) greater than or equal to 2.0 was associated with an acute overdose. This ratio was more useful than total plasma levels in differentiating an overdose from a therapeutic dose with associated toxicity and an elevated steady-state plasma level.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antidepresivos Tricíclicos
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Psychiatry
Año:
1978
Tipo del documento:
Article