Porphyria turcica. Twenty years after hexachlorobenzene intoxication.
Arch Dermatol
; 116(1): 46-50, 1980 Jan.
Article
en En
| MEDLINE
| ID: mdl-7352763
ABSTRACT
Porphyria involving more than 4,000 persons occurred in Eastern Turkey from 1956 to 1961 due to ingestion of hexachlorobenzene (HCB), a fungicide added to wheat seedlings. During a site visit in 1977, 32 porphyric Turks (mean age, 29 years) were examined. Porphyrin concentrations were determined with samples of urine and stool from 29 porphyric and 10 control Turks and compared with results from 40 subjects in the United States. Distinctive clinical features were found in porphyric subjects, including hyperpigmentation, hirsutism, severe scarring, short stature, pinched facies, small hands, painless arthritis, weakness, and enlarged thyroids. Porphyrin levels were still substantially elevated in five subjects. Hexachlorobenzene, which is fat soluble, was detected in maternal milk of one porphyric patient and in one other patient's fat. The level of HCB was not considered sufficient to account for persistence of porphyria but may be a clue to the cause of pembe yara (pink sore), in which many children who were breast-fed by affected mothers died with associated weakness, convulsions, and annular erythema.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Porfirias
/
Enfermedades de la Piel
/
Clorobencenos
/
Hexaclorobenceno
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
/
Newborn
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch Dermatol
Año:
1980
Tipo del documento:
Article