Remyelination during optic nerve compression.
J Neurol Sci
; 46(2): 239-43, 1980 May.
Article
en En
| MEDLINE
| ID: mdl-7381514
ABSTRACT
The structural changes produced in cat optic nerve by incremental chronic compression have been investigated by light and electron microscopy. Within the first week extensive demyelination occurred; some fibres underwent Wallerian degeneration and there was marked proliferation of astrocytic processes. After 5 weeks of compression remyelinated fibres were seen and occurred in all longer-term animals despite the maintenance of compression, but some partially and completely demyelinated fibres persisted. Myelin thickness had not returned to normal in the remyelinated fibres after 19 weeks and was often strikingly variable. The significance of these observations is discussed in the light of the recent demonstration of the restoration of central conduction by remyelination.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades del Nervio Óptico
/
Vaina de Mielina
/
Síndromes de Compresión Nerviosa
/
Regeneración Nerviosa
Límite:
Animals
Idioma:
En
Revista:
J Neurol Sci
Año:
1980
Tipo del documento:
Article