Coexpression of TGF alpha, epidermal growth factor receptor, and P-glycoprotein in normal and benign diseased breast tissues.
Diagn Mol Pathol
; 4(2): 136-42, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7551294
ABSTRACT
Twenty-four normal or benign breast tissues were examined for the expression of transforming growth factor-alpha (TGF alpha), epidermal growth factor receptor (EGFR), and P-glycoprotein, the product of the mdr-1 gene. Specific staining for all three proteins was observed in the majority of the samples. P-glycoprotein staining was present in most (88%), and confined to the lumenal surface of the ductal epithelium. Membranous EGFR expression was observed in epithelial cells in 92% of the specimens and 42% displayed both myoepithelial and epithelial cell staining. TGF alpha staining was intense and uniformly distributed through the cytoplasm (96%). Coexpression of EGFR, TGF alpha, and P-glycoprotein in normal human breast tissues suggests a role for each of those proteins in normal breast physiology. An interaction may be present in normal breast tissue between the EGF receptor pathway and P-glycoprotein.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mama
/
Enfermedades de la Mama
/
Neoplasias de la Mama
/
Biomarcadores de Tumor
/
Factor de Crecimiento Transformador alfa
/
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
/
Receptores ErbB
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Diagn Mol Pathol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
PATOLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos