Tamoxifen and somatostatin affect tumours by inducing apoptosis.
Cancer Lett
; 96(1): 141-5, 1995 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-7553602
ABSTRACT
Tamoxifen is a commonly used chemotherapeutic agent in human breast cancer, although some tumours develop resistance. Somatostatin is also being introduced as an anti-tumour agent. Here we show that the action of these drugs is, at least partly, due to their induction of apoptosis. Both 50 nM somatostatin, and 60 nM tamoxifen significantly enhanced the percentage of cells undergoing apoptosis, when compared to untreated or oestrogen treated control cells. This effect was observed in SK-N-BE(2) human neuroblastoma cells and in MCF-7G human breast cancer cells but not in their drug-resistant counterpart MCF-7A which showed a very low rate of spontaneous programmed cell death. Finally, we propose a simple test of the sensitivity and resistance of individual tumours to these agents by assessing their ability to induce apoptosis in vitro as measured by flow cytometry.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tamoxifeno
/
Neoplasias de la Mama
/
Somatostatina
/
Apoptosis
/
Neuroblastoma
/
Antineoplásicos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia