Gamma delta T cells in human decidua.
Am J Obstet Gynecol
; 168(3 Pt 1): 831-6, 1993 Mar.
Article
en En
| MEDLINE
| ID: mdl-8096118
ABSTRACT
OBJECTIVE:
Our purpose was to assess the presence and frequency of gamma delta T cells in the decidua of term and first-trimester pregnancies. STUDYDESIGN:
Term and first-trimester placentas were obtained from normal subjects. Frozen sections and cell suspensions were prepared from decidual tissue and stained with monoclonal antibodies to T cell markers. Cell sorter analysis was performed.RESULTS:
gamma delta T cells in term decidual cell preparations were enriched 2.4-fold compared with peripheral blood. Immunohistochemical staining of term decidual tissue demonstrated many gamma delta + and CD3+ T cells, fewer CD8+ cells, and rare CD4+ cells. In contrast, first-trimester decidua was found to be devoid of gamma delta + T cells, by both cell sorter analysis and immunohistochemical methods.CONCLUSIONS:
Term, but not early, decidua harbors a resident T-cell population that is significantly enriched in gamma delta T cells compared with blood. These lymphocytes may provide an added defense mechanism against infection during the peripartum.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Subgrupos de Linfocitos T
/
Decidua
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1993
Tipo del documento:
Article