Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.
Gene
; 124(2): 183-9, 1993 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-8166882
ABSTRACT
The complete nucleotide sequence of the coding region of hedgehog (hh), a segment-polarity gene in Drosophila melanogaster, was determined. The gene was found to include three exons which would encode a 421- (or 471-) amino acid (aa) polypeptide with a long hydrophobic stretch. The hh mRNA was about 2.3 kb long and expressed throughout development. The hh expression in an embryo occurred in stripes, while that in imaginal discs occurred in the posterior compartment. As a whole, the spatial expression pattern of hh mRNA was very similar to that of engrailed (en), a homeobox gene required for the formation of the anterior-posterior compartment boundary. Unlike en, no hh expression was observed in the central nervous system.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas
/
Comunicación Celular
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Gene
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón