Basal ganglia iron in tardive dyskinesia: an MRI study.
Biol Psychiatry
; 35(1): 16-21, 1994 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-8167198
ABSTRACT
Alterations in brain iron could play an important role in the development of tardive dyskinesia in patients receiving neuroleptic medication. To test this hypothesis, magnetic resonance imaging scans of the brain were performed on 21 chronic schizophrenic patients. Ten patients met research diagnostic criteria for persistent tardive dyskinesia, and 11 were free of tardive dyskinesia. All patients had received long-term neuroleptic treatment and were on a stable neuroleptic dose for at least 3 months before scanning. The signal intensity of basal ganglia structures was obtained as a quantitative estimate of brain iron content. No difference was found in the signal intensity ratios between the two groups. This suggests that iron deposition in the basal ganglia, at least as assessed by this measure, does not play a role in the pathophysiology of tardive dyskinesia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ganglios Basales
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Imagen por Resonancia Magnética
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Discinesia Inducida por Medicamentos
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Hierro
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Año:
1994
Tipo del documento:
Article