d-alpha-tocopherol control of cell proliferation.
Mol Aspects Med
; 14(3): 265-71, 1993.
Article
en En
| MEDLINE
| ID: mdl-8264342
ABSTRACT
Uncontrolled cell growth is at the basis of neoplastic proliferation and arteriosclerotic lesions. In vitro proliferation of vascular smooth muscle cells, Balb c/3T3 fibroblasts, retinal neuroepithelial cells and neuroblastoma cells is inhibited by d-alpha-tocopherol. On the contrary Chinese hamster ovary cells, osteosarcoma cells and macrophages are not sensitive. PDGF-BB activated proliferation is highly d-alpha-tocopherol sensitive while lysophosphatidic acid induced growth is poorly inhibited. d-beta-Tocopherol, an analogue of d-alpha-tocopherol, with similar antioxidant properties, does not inhibit proliferation. Protein kinase C activity is inhibited by d-alpha-tocopherol but not by d-beta-tocopherol, suggesting a central role of this enzyme in the control of cell proliferation by d-alpha-tocopherol. Activation of the transcription activation complex AP-1 (but not NFKB) is prevented by d-alpha-tocopherol and not by d-beta-tocopherol.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vitamina E
/
División Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Aspects Med
Año:
1993
Tipo del documento:
Article
País de afiliación:
Suiza