Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients.
Immunol Res
; 12(1): 12-20, 1993.
Article
en En
| MEDLINE
| ID: mdl-8390552
ABSTRACT
The T-cell receptor V beta subfamily repertoires of synovial and peripheral T cells of 8 rheumatoid arthritis (RA) patients were determined using the polymerase chain reaction. Three normal controls were included. Some of the rheumatoid synovial samples did not express the complete range of V beta families and lacked as many as 6 gene families. However, these patients showed considerable individual variation in expression. Overall, the data do not support preferential T-cell receptor V beta usage in synovial T cells of RA patients either in comparison to their autochthonous peripheral T cells or to peripheral T cells of normal subjects.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Membrana Sinovial
/
Linfocitos T
/
Receptores de Antígenos de Linfocitos T alfa-beta
/
Reordenamiento Génico de la Cadena beta de los Receptores de Antígenos de los Linfocitos T
Límite:
Humans
Idioma:
En
Revista:
Immunol Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1993
Tipo del documento:
Article
País de afiliación:
Turquía