Low-dose dopamine induces early recovery of recombinant interleukin-2--impaired renal function.
Eur J Cancer
; 29A(8): 1119-22, 1993.
Article
en En
| MEDLINE
| ID: mdl-8518023
ABSTRACT
Recombinant interleukin-2 (rIL-2) can produce impairment of renal function with hypotension, fluid retention, elevated blood urea nitrogen, oliguria and low fractional sodium excretion; these side-effects are a common cause of reduction or interruption of rIL-2 infusion. The aim of this study was to investigate the control and treatment of renal toxicity induced by rIL-2 therapy. Here we show that dopamine, at a low dose of 2 micrograms/kg/min, completely prevented renal toxicity induced by rIL-2. While continuing rIL-2 therapy, 24-h continuous infusion of low-dose dopamine produced a rapid normalisation of urine output and a significant decrease in serum creatinine levels and body weight (P < 0.01), with an early and complete recovery of the rIL-2--impaired renal function mean recovery time of renal function in patients treated with dopamine was significantly lower (P < 0.05) than in nontreated patients (4.8 days vs. 10 days, respectively).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dopamina
/
Interleucina-2
/
Enfermedades Renales
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Cancer
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia