Reliability of sequential naloxone challenge tests.
Am J Drug Alcohol Abuse
; 21(4): 453-67, 1995 Nov.
Article
en En
| MEDLINE
| ID: mdl-8561097
ABSTRACT
To determine the reliability of serial naloxone challenges, five heroin addicts stabilized on methadone were given 0.2 mg naloxone intravenously on three consecutive days. Two-factor ANOVA revealed that the between-subjects effect accounted for at least 63% of the variance in each of the dependent measures, and the effect of challenge number for at most 22%. Withdrawal tended to be slightly more severe for the first challenge. Intraclass correlation coefficients were calculated for the area-under-the-curve of the change from baseline subject-rated (.74) and observer-rated (.71) withdrawal, pulse (.88), systolic blood pressure (.58), diastolic blood pressure (.85), and skin temperature (.63).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Reproducibilidad de los Resultados
/
Naloxona
/
Antagonistas de Narcóticos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Drug Alcohol Abuse
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos