In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.
Science
; 272(5259): 263-7, 1996 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-8602510
ABSTRACT
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
VIH
/
Técnicas de Transferencia de Gen
/
Vectores Genéticos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Science
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos