Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.
J Antibiot (Tokyo)
; 49(3): 230-3, 1996 Mar.
Article
en En
| MEDLINE
| ID: mdl-8626235
ABSTRACT
5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Tacrolimus
/
Proteínas de Unión al ADN
/
Proteínas de Choque Térmico
/
Micromonospora
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suiza