1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
J Med Chem
; 39(16): 3195-202, 1996 Aug 02.
Article
en En
| MEDLINE
| ID: mdl-8759642
ABSTRACT
The synthesis and binding profile on 5-HT1A, 5-HT2, D-1, D-2, alpha 1, and alpha 2 receptors of the N-4 long-chain arylpiperazines 22-40 are reported, where an amino or amido function is inserted into the intermediate chain linked to the alpha position of the tetralin nucleus. Unlike the buspirone analogues, for the amido derivatives studied in this paper, the terminal amide function of long-chain piperazines is not important for 5-HT1A receptor affinity binding, and its removal yields high-affinity 5-HT1A receptor agents.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Receptores de Serotonina
/
Agonistas de Receptores de Serotonina
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia