Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.
FEBS Lett
; 394(2): 206-12, 1996 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-8843165
ABSTRACT
Following the identification of a M. tuberculosis phosphate transporter belonging to the superfamily of ABC transporters, we report on the cloning and sequencing of two additional genes, called pstS-3 and pstC-2, encoding proteins homologous to PstS and PstC of Escherichia coli, respectively. Together with the previously isolated M. tuberculosis gene similar to the E. coli pstA, these are included in a cluster encoding a second putative phosphate transport system. We demonstrate that pstS-3 encodes the previously described Ag 88, a 40 kDa M. bovis BCG culture filtrate antigen (immunodominant in H-2b haplotype type mice). Finally, a signature motif identifying integral transmembrane proteins of prokaryotic phosphate binding-dependent permeases is proposed.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Proteínas Portadoras
/
Familia de Multigenes
/
Transportadoras de Casetes de Unión a ATP
/
Mycobacterium tuberculosis
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
FEBS Lett
Año:
1996
Tipo del documento:
Article
País de afiliación:
Bélgica