[The detection of tramadol and its metabolites in urine by chromatographic methods]. / Obnaruzhenie tramadola i ego metabolitov v moche khromatograficheskimi metodami.
Sud Med Ekspert
; 39(4): 38-43, 1996.
Article
en Ru
| MEDLINE
| ID: mdl-9026968
ABSTRACT
The authors recommend detecting a compound drug tramadol and its metabolites in urinary extracts by thin-layer, gas-chromatographic, high-pressure liquid, and other chromatographic methods. The metabolites were identified with due consideration for their fragmentation during an electron strike thereof and their trimethylsilyl derivatives, mobility during separation in a thin layer, and results of selective extraction at various pH. The proposed scheme of biotransformation includes the formation of products of O- and N- demethylation, N, N- and N,O-didemethylation and hydroxylation of the cyclohexane fragment. The Rf metabolite values and their mass spectra are presented. During gas chromatographic analysis at an evaporator temperature at least 250 degrees C tramadol undergoes thermal destruction with the formation of water molecules and cyclohexane structure.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tramadol
/
Analgésicos Opioides
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Ru
Revista:
Sud Med Ekspert
Año:
1996
Tipo del documento:
Article