Low peripheral plasma renin activity as a critical marker in pediatric hypertension.
Pediatr Nephrol
; 11(3): 343-6, 1997 Jun.
Article
en En
| MEDLINE
| ID: mdl-9203188
ABSTRACT
In evaluating hypertensive children and adolescents, the etiological considerations should include a set of inherited disorders that share very low plasma renin activity (PRA) as a common feature. In particular among these disorders, glucocorticoid remediable aldosteronism (GRA) appears to be emerging as an important etiology of hypertension in the pediatric population. We report the evaluation of a 9-year-old Caucasian girl who presented with severe hypertension and a strong family history of early-onset hypertension. Her suppressed PRA, her family history, and her failure to respond to conventional anti-hypertensive therapy raised GRA as a potential etiology. The diagnosis was confirmed by an elevated ratio of urinary 18-oxotetrahydrocortisol to urinary tetrahydroaldosterone and genetic testing, which demonstrated the chimeric gene duplication. The molecular pathogenesis of GRA and the clinical implications are reviewed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Renina
/
Hipertensión
Tipo de estudio:
Etiology_studies
Límite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Pediatr Nephrol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos