Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle.
Int J Exp Pathol
; 78(2): 57-70, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9203980
ABSTRACT
The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger RNA for vascular endothelial growth factor (VEGF). Angiogenic activity, mediated by VEGF, is manifested in the peripheral blood vessels surrounding the follicle, that show capillary sprouting and increased vascular permeability. Following ovulation, rapid infiltration of capillaries through the follicular wall is essential for the formation of the corpus luteum. In this review we compare the preovulatory follicle with a popular model of avascular solid tumour growth, namely the multicellular tumour spheroid, in particular the role of hypoxic stress in the regulation of angiogenesis in both systems.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipoxia de la Célula
/
Factores de Crecimiento Endotelial
/
Linfocinas
/
Neovascularización Fisiológica
/
Folículo Ovárico
/
Neoplasias
/
Neovascularización Patológica
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Int J Exp Pathol
Asunto de la revista:
PATOLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Israel