Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
Science
; 280(5369): 1614-7, 1998 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-9616126
ABSTRACT
The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN inhibited cell migration, whereas antisense PTEN enhanced migration. Integrin-mediated cell spreading and the formation of focal adhesions were down-regulated by wild-type PTEN but not by PTEN with an inactive phosphatase domain. PTEN interacted with the focal adhesion kinase FAK and reduced its tyrosine phosphorylation. Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adhesión Celular
/
Movimiento Celular
/
Proteínas Tirosina Fosfatasas
/
Monoéster Fosfórico Hidrolasas
/
Proteínas Supresoras de Tumor
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos