DNA vaccines against tuberculosis.

Ulmer, J B; Montgomery, D L; Tang, A; Zhu, L; Deck, R R; DeWitt, C; Denis, O; Orme, I; Content, J; Huygen, K

Ulmer, J B; Montgomery, D L; Tang, A; Zhu, L; Deck, R R; DeWitt, C; Denis, O; Orme, I; Content, J; Huygen, K.

Afiliación

Ulmer JB; Department of Virus and Cell Biology, Merck Research Laboratories, West Point, PA 19486, USA.

Novartis Found Symp ; 217: 239-46; discussion 246-53, 1998.

Article en En | MEDLINE | ID: mdl-9949812

ABSTRACT

ABSTRACT

DNA plasmids encoding Mycobacterium tuberculosis antigen 85 (Ag85) were tested as vaccines in animal models. Ag85 DNA induced relevant immune responses (i.e. T helper (Th) cells, Th1 cytokines and cytotoxic T lymphocytes) and was protective in mouse and guinea pig models of mycobacterial disease. Therefore, DNA vaccination holds promise as an effective means of preventing tuberculosis in humans. Furthermore, this technique is amenable to identifying the protective antigens of M. tuberculosis.

Asunto(s)

Aciltransferasas; Antígenos Bacterianos/inmunología; Vacuna BCG/uso terapéutico; Tuberculosis Pulmonar/prevención & control; Vacunas de ADN/uso terapéutico; Animales; Anticuerpos Antibacterianos/sangre; Antígenos Bacterianos/genética; Vacuna BCG/inmunología; Femenino; Cobayas; Inmunidad Celular; Ratones; Ratones Endogámicos BALB C; Vacunación; Vacunas de ADN/inmunología

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Aciltransferasas / Vacuna BCG / Vacunas de ADN / Antígenos Bacterianos Límite: Animals Idioma: En Revista: Novartis Found Symp Asunto de la revista: MEDICINA Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos

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